The 99er Pattern

The unnaturally high PO₂ usually occurs when blood cannot reach
tissues due to endothelial capillary inflammation. The endothelial inflammation reduces below the passable diameter of a red
blood cell (RBC). When this occurs, only plasma can flow through the
capillaries, limiting energy production to anaerobic fueled by
glucose absent oxygen.

Explanation

The reduced capillary cross section causes RBCs to go around narrowed
capillaries. RBCs that don’t pass through capillaries do not release
oxygen much like a vehicle that cannot release a payload — it
just remains full. This shows up as an unnaturally high starting
PO₂ and a tendency NOT to desaturate during hypoxic
exertion challenge.

This pattern has been observed:

• Fibromyalgia / Chronic Fatigue
• Cancer patients after chemotherapy

For comparison a starting saturation level of about 97%, with
rapid desaturation to 87%, is normal (sea level).

This pattern contradicts the typical medical conclusion that a high
hemoglobin saturation indicates good tissue oxygenation. The medical
interpretation presumes, usually incorrectly, that oxygen can always
move from the RBC to tissue. By the time this saturation pattern,
99-100%, occurs when the person’s body has a large percentage of
under-oxygenated tissue.

The severity of systemic hypoxia is indicated by how long it takes
them to resaturate after the inflammation is reversed. On the pulse
oximeter, how many minutes does it take them to saturate to 99% after
they reperfuse dip? The longer the time, the greater the accumulated
oxygen tissue debt.

The degree of systemic hypoxia is indicated by how long it takes the
person to resaturate afterwards (the amount of time the person spends
on oxygen with a low oxygen level).

The problem is that the oxygen bound to hemoglobin cannot dissociate
because it never passes through the capillaries where it can release
oxygen. In this case, unnaturally high hemoglobin saturation means
poor tissue oxygenation.

Resolution Pattern

The telltale for resolution of this pattern is a dramatic drop in
PO₂ late in the session while on oxygen. Here is a model
for what happens:

1. Capillary pulse pressure reaches the penetration threshold as
   arterial blood pressure and hypoxia-induced vasodilation deliver
   more pressure to capillary bed. This takes effort and some time.
   It does not happen instantly, and takes 5-10 minutes of effort.
2. Endothelial cells switch back to normal metabolism and pump out
   sodium and quickly shrink back to normal size
3. Capillary opens to red blood cell passage and tissue reoxygenation begins
4. PO2 drops as tissues absorb large amount of oxygen until
   reperfusion is complete, usually in 2-4 minutes.

Started abnormally high 99% PO₂ on start and then desaturated to 80% after hypoxic challenge about 9 minutes into the session. User remained at 80% PO₂ for 2 minutes while breathing oxygen. Normal resaturation time is 5 seconds.

Resolution Pattern

The telltale for resolution of this pattern is a dramatic drop in PO₂ late in the session while on oxygen. Here is a model for what happens:

1. Capillary pulse pressure reaches the penetration threshold as arterial blood pressure and hypoxia-induced vasodilation deliver more pressure to capillary bed. This takes effort and some time ; it does not happen instantly, and takes 5-10 minutes of effort.
2. Endothelial cells switch back to normal metabolism and pump out sodium and quickly shrink back to normal size
3. Capillary opens to red blood cell passage and tissue re-oxygenation begins
4. PO₂ drops as tissues absorb large amount of oxygen until re-perfusion is complete, usually in 2-4 minutes.

Pathological Vector

This is the typical chronic-fatigue pattern. It usually includes persistent muscle touch sensitivity from regional tissue acidosis. Over time this condition can progress to multiple local and systemic disease states:

• Hypoglycemia as under-oxygenated tissues use excessive glucose. If the liver fails to keep up with demand, then blood sugar falls to hypoglycemic levels and causes systemic fatigue.
• Gall bladder conditions including discomfort and gallstones. When the cori cycledepletes lactic acid reacts with bile in the gall bladder to precipitate solids which often form gallstones and cause discomfort.
• This author suggests that tissues that retain excess lactic acid for a long time become hypersensitive as with fibromyalgia.

See Fatigue Protocol for more information.

Protocol

• Whole Body Flush

Reproducibility

Normally this pattern only occurs once during early use. Re-perfusion is durable until conditions that caused endothelial inflammation recur.

LiveO₂ Adaptive Contrast appears to be a requirement to provoke resaturation. It seems the reason for this is that reduced-oxygen air creates vasodilation and increases arterial pulse pressure, which maximizes pulse pressure at the capillary entrance. This re-perfusion effect has not been observed with LiveO₂ Standard.

What to Expect

If you experienced this pattern, you will likely:

• Feel stronger and have increased endurance
• Reduced cravings for sweets and simple carbohydrates
• Reduced tendency for muscle soreness
• Greater strength in major muscles
• Reduced tendency for loose stools
• Improved fat digestion from improved bile availability
• Have an increased respiration rate at rest